£HEALTHY MALES 18-35yrs NEEDED£:

We are looking to recruit:
- Healthy males
- Caucasian & first language English
- Completing a degree or have already graduated
- Aged 18-30yrs
- Right handed
- Non-smokers & non-recreational drug users
- Volunteers available in July, August OR September.

Participation will involve:
Coming to the Institute of Psychiatry(Camberwell) on 3 occasions (each separated by 14 days) from 10am – 4:30pm. On each visit you will be asked to:
- Ingest a low dose of medication or a placebo (intended to stimulate dopaminergic changes in the brain; may cause
restlessness, agitation, nausea or short-lived 'dystonic reaction' involving spasm
of certain muscle groups)
- provide a blood sample equivalent to 3.5 teaspoons
- provide cheek swabs and saliva samples
- have an MRI scan whilst completing some computer tasks
- complete questionnaires (rate mood & provide socio-demographic information)

Purpose of the project:
As part of a larger study investigating genetics and psychiatric illnesses, we are trying to find out how medications called haloperidol and aripiprazole (used to treat various types of mental illness such as psychosis) affect the brain. Exploring these effects in healthy individuals enables us to better understand the role of these drugs in the treatment of mental health.

Lunch is provided, TRAVEL EXPENSES AND YOUR TIME WILL BE REIMBURSED.

Brain images can be provided on request.

Interested or like to know more? Please email rowena.handley@iop.kcl.ac.uk :
- a contact number
- the postcode of your current address (or address for the summer)

The Joint South London and Maudsley and The Institute of Psychiatry NHS Research Ethics Committee reference: 05/Q0706/158 (135/05).